1 Alpha,25-dihydroxyvitamin D3 rapidly increases cytosolic calcium in clonal rat osteosarcoma cells lacking the vitamin D receptor.

@article{Baran19911AD,
  title={1 Alpha,25-dihydroxyvitamin D3 rapidly increases cytosolic calcium in clonal rat osteosarcoma cells lacking the vitamin D receptor.},
  author={Daniel T. Baran and Ann M. Sorensen and Victoria Shalhoub and Teresa Owen and A M Oberdorf and Gary Stein and Jane B Lian},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1991},
  volume={6 12},
  pages={1269-75}
}
1 alpha,25-Dihydroxyvitamin D3 [1 alpha,25-(OH)2D3] rapidly increases cytosolic calcium in a variety of cell types. Although these rapid effects do not appear to directly involve genome activation, the requirement for the classic vitamin D receptor is unclear. Clonal rat osteosarcoma cells, ROS 17/2.8, respond to 1 alpha,25-(OH)2D3 with an increase in osteocalcin message but ROS 24/1 cells do not. The lack of the receptor for vitamin D in the ROS 24/1 cells has been confirmed by the absence of… CONTINUE READING