1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression

@article{Sakai20091Alpha2V,
  title={1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression},
  author={Sadaoki Sakai and Hironari Takaishi and Kenichiro Matsuzaki and Hironori Kaneko and Mitsuru Furukawa and Yoshiteru Miyauchi and Ayako Shiraishi and Keiji Saito and Akio Tanaka and T. Taniguchi and Toshio Suda and Takeshi Miyamoto and Yoshiaki Toyama},
  journal={Journal of Bone and Mineral Metabolism},
  year={2009},
  volume={27},
  pages={643-652}
}
1-Alpha, 25-dihydroxy vitamin D3 (1α,25(OH)2D3), an active form of vitamin D3, plays a critical role in calcium and bone metabolism. Although 1α,25(OH)2D3 has been used for osteoporosis therapy, the direct role of 1α,25(OH)2D3 on human osteoclastogenesis has not been well characterized. Here we show that 1α,25(OH)2D3 treatment significantly inhibited human osteoclast formation at the early stage of differentiation in a concentration-dependent manner. 1α,25(OH)2D3 inhibited the expression of… CONTINUE READING