1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities.

@article{SalginGken20071Acylthiosemicarbazides11,
  title={1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities.},
  author={Umut Salgin-G{\"o}kşen and Nesrin G{\"o}khan-Kelekçi and Ozg{\"u}r G{\"o}ktaş and Yavuz K{\"o}ysal and Ekrem Kiliç and S Sinan Isik and G{\"o}knur Aktay and Meral Ozalp},
  journal={Bioorganic & medicinal chemistry},
  year={2007},
  volume={15 17},
  pages={5738-51}
}
Acetic acid hydrazide containing 5-methyl-2-benzoxazolinone (4) was synthesized by the condensation of 2-(5-methyl-2-benzoxazolinone-3-yl)acetate with hydrazine hydrate. Thiosemicarbazide derivatives (5a-5d) were afforded by the reaction of corresponding compound 4 with substituted isothiocyanates. The cyclization of compounds 5a-5d in the presence of triethylamine resulted in the formation of compounds 6a-6d containing 1,2,4-triazole ring. On the other hand, the treatment of compounds 5a-5d… CONTINUE READING

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