1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) exerts an anorexic action that is blocked by 5-HT2 antagonists in rats

@article{Schechter2004125Dimethoxy4iodophenyl2aminopro,
  title={1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) exerts an anorexic action that is blocked by 5-HT2 antagonists in rats},
  author={Lee E. Schechter and Kenny J. Simansky},
  journal={Psychopharmacology},
  year={2004},
  volume={94},
  pages={342-346}
}
Previous literature suggests that the anorexic action of peripherally administered serotonin (5-HT) is mediated by 5-HT2 receptors. This study, therefore, examined the effect of DOI, a non-indole 5-HT2 agonist, on deprivation-induced feeding. Rats were first adapted to a schedule in which a milk diet was presented for 6 h daily. Intraperitoneal (IP) administration of DOI (1.0–11.2 μmol/kg) inhibited feeding in a dose-related fashion (ID50=2.6 μmol/kg). One hour pretreatment with 6.0 μmol/kg of… Expand
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The food intake suppressant effects of various doses of DOI were found to be similar in the Fawn-Hooded rat strain as compared to the Wistar rat strain, suggesting that DOI-induced suppression of food intake is mediated by stimulation of both 5-HT1C and5-HT2 receptors. Expand
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TLDR
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Effects of tryptophan and of 5-hydroxytryptamine receptor subtype agonists on feeding.
  • G. Curzon
  • Biology, Medicine
  • Advances in experimental medicine and biology
  • 1991
TLDR
5-HT1A agonists (8-OH-DPAT, buspirone, gepirone etc.) stimulate intake in freely feeding rats, probably by activating autoreceptors on the cell bodies of 5- HT neurons so that 5-HT release at terminals is decreased and feeding in previously food deprived rats is decreased. Expand
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