1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: a novel series of highly potent revertants of P-glycoprotein associated multidrug resistance.

@article{Das2008142Aminoethoxyphenylcarbonyl35bisbenzy,
  title={1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: a novel series of highly potent revertants of P-glycoprotein associated multidrug resistance.},
  author={Umashankar Das and J{\'o}zsef Moln{\'a}r and Zolt{\'a}n Bar{\'a}th and Zsuzsanna Bata and Jonathan R. Dimmock},
  journal={Bioorganic & medicinal chemistry letters},
  year={2008},
  volume={18 12},
  pages={3484-7}
}
The 1-[4-(2-aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines 5-8 are a novel cluster of highly potent P-glycoprotein dependent multidrug resistance (MDR) revertants. Using a concentration of 4mug/mL, these compounds possess 11-43 times the potency of verapamil in reversing MDR in murine L-5178 lymphoma cells transfected with the human MDR1… CONTINUE READING