1‐Methyl‐3‐propyl‐7‐butylxanthine, a Novel Biochemical Modulator, Enhances Therapeutic Efficacy of Adriamycin

@article{Sadzuka19981Methyl3propyl7butylxanthineAN,
  title={1‐Methyl‐3‐propyl‐7‐butylxanthine, a Novel Biochemical Modulator, Enhances Therapeutic Efficacy of Adriamycin},
  author={Yasuyuki Sadzuka and Ayano Iwazaki and Tomomi Sugiyama and Takayuki Sawanishi and Ken‐ichi Miyamoto},
  journal={Japanese Journal of Cancer Research : Gann},
  year={1998},
  volume={89},
  pages={228 - 234}
}
We have screened xanthine derivatives for activity as novel biochemical modulators by assay of their inhibitory effect on adriamycin efflux from tumor cells. Strong inhibition of adriamycin efflux was shown by some xanthine derivatives with various alkyl or oxoalkyl substituents at the 1‐, 3‐ and 7‐positions. 1‐Methyl‐3‐propyl‐7‐butylxanthine (XT‐77), which had the greatest inhibitory effect on adriamycin efflux in vitro among the compounds tested, potentiated adriamycin‐induced antitumor… 
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