1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients.

@article{Mizwicki2013125dihydroxyvitaminDA,
  title={1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients.},
  author={Mathew T. Mizwicki and Guanghao Liu and Milan Fiala and Larry I. Magpantay and James W. Sayre and Avi Siani and Michelle Mahanian and Rachel Weitzman and Eric Y Hayden and Mark J. Rosenthal and Ilka Nemere and John M. Ringman and David B Teplow},
  journal={Journal of Alzheimer's disease : JAD},
  year={2013},
  volume={34 1},
  pages={155-70}
}
As immune defects in amyloid-β (Aβ) phagocytosis and degradation underlie Aβ deposition and inflammation in Alzheimer's disease (AD) brain, better understanding of the relation between Aβ phagocytosis and inflammation could lead to promising preventive strategies. We tested two immune modulators in peripheral blood mononuclear cells (PBMCs) of AD patients and controls: 1α,25(OH)2-vitamin D3 (1,25D3) and resolvin D1 (RvD1). Both 1,25D3 and RvD1 improved phagocytosis of FAM-Aβ by AD macrophages… CONTINUE READING

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