1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.

@article{Durk2012125DihydroxyvitaminDV,
  title={1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.},
  author={Matthew R. Durk and Gary N Y Chan and Christopher R Campos and John C Peart and Edwin Chiu Yuen Chow and Eason Lee and Ronald E. Cannon and Reina Bendayan and David Scott Miller and K Sandy Pang},
  journal={Journal of neurochemistry},
  year={2012},
  volume={123 6},
  pages={944-53}
}
Induction of the multidrug resistance protein 1 (MDR1)/P-glycoprotein (P-gp) by the vitamin D receptor (VDR) was investigated in isolated rat brain capillaries and rat (RBE4) and human (hCMEC/D3) brain microvessel endothelial cell lines. Incubation of isolated rat brain capillaries with 10 nM of the VDR ligand, 1α,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] for 4 h increased P-gp protein expression fourfold. Incubation with 1,25(OH)(2)D(3) for 4 or 24 h increased P-gp transport activity… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Effects of 1 a , 25dihydroxyvitamin D 3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco2 cells

  • J. MaengH., H. Chapy, S. Zaman, S. PangK.
  • Eur . J . Pharm . Sci .
  • 2012

Genomic and nongenomic signaling induced by 1 a , 25 ( OH ) 2vitamin D 3 promotes the recovery of amyloidb phagocytosis by Alzheimer ’ s disease macrophages

  • T. MizwickiM., D. Menegaz, +5 authors M. Fiala
  • J . Alzheimers Dis .
  • 2012

The effect of vitamin D 3 and ketoconazole combination on VDRmediated Pgp expression and function in human colon adenocarcinoma cells : implications in drug disposition and resistance

  • P. KotaB., D. AllenJ., D. RoufogalisB.
  • Basic Clin . Pharmacol . Toxicol .
  • 2011

Alzheimer ’ s disease

  • W. QuerfurthH., M. LaFerlaF.
  • N . Engl . J . Med .
  • 2010

Similar Papers

Loading similar papers…