1α,25-(OH)2-Vitamin D3Analogs with Minimalin VivoCalcemic Activity Can Stimulate Significant Transepithelial Calcium Transport and mRNA Expressionin Vitro☆☆☆

@inproceedings{Fleet1996125OH2VitaminDW,
  title={1α,25-(OH)2-Vitamin D3Analogs with Minimalin VivoCalcemic Activity Can Stimulate Significant Transepithelial Calcium Transport and mRNA Expressionin Vitro☆☆☆},
  author={James C. Fleet and Jessica L. Bradley and Gudimetla Satyanarayana Reddy and Rahul Ray and Richard James Wood},
  year={1996}
}
Several 1α,25-(OH)2-vitamin D3(1α,25-(OH)2-D3) analogs have significant antiproliferative effectsin vitrobut do not elevate serum calciumin vivo.We tested whether the lack of a calcemic response of a vitamin D analogin vivois due to its inability to stimulate intestinal calcium absorption by examining the effect of several such compounds on transepithelial calcium transport in the human colonic carcinoma cell line Caco-2. The relative stimulations of calcium transport by the four A-ring… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Vitamin D and metabolites measurement by tandem mass spectrometry

Johannes M. W. van den Ouweland, Michael Vogeser, Silvia Bächer
  • Reviews in Endocrine and Metabolic Disorders
  • 2013