1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling.

@article{Nair19951N6ethenodeoxyadenosineA3,
  title={1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling.},
  author={J. Hariharan Nair and Alain Barbin and Y Guichard and Helmut Bartsch},
  journal={Carcinogenesis},
  year={1995},
  volume={16 3},
  pages={613-7}
}
The etheno-bridged exocyclic DNA adducts 1,N6-ethenodeoxyadenosine (epsilon dA) and 3,N4-ethenodeoxycytine (epsilon dC) can be formed by several structurally diverse carcinogens and mutagens that include vinyl chloride and urethane. In order to investigate the occurrence and persistence of these adducts in rodents exposed to such DNA-damaging agents, an ultra-sensitive detection method has been developed. It is based on immunoaffinity purification of the etheno adducts and subsequent 32P… CONTINUE READING

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