• Corpus ID: 39595555

1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal.

  title={1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal.},
  author={Rama S. Sodum and Fung-Lung Chung},
  journal={Cancer research},
  volume={48 2},
The reaction of trans-4-hydroxy-2-nonenal, a major alpha, beta-unsaturated aldehyde released during lipid peroxidation, with deoxyguanosine under physiological conditions was investigated in order to assess its DNA damaging potential. This aldehyde was dissolved in tetrahydrofuran (THF) prior to addition to the reaction mixture. The results showed that structurally different adducts were formed in these reactions depending on the THF used. Using THF unprotected from light, reactions yielded… 
Characterization of 2'-deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product.
Analysis of the reaction between 2'-deoxycytidine and 4-oxo-2-nonenal by LC/MS and NMR spectroscopy revealed the presence of three major products (adducts A(1), A(2), and B; [M + H](+) = 364).
Formation of Cyclic l , A ^ 2-Propanodeoxyguanosine and Thymidine Adducts in the Reaction of the Mutagen 2-Bromoacrolein with Calf Thymus DNA 1
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Stereoselective formation of in vitro nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal.
RNA was extensively modified by the epoxy aldehyde, yielding both adenine and guanine nucleosides, and reactions of single-stranded DNA resulted in the formation of primarily A1 and A2, with a total adduct level of 30 nmol/mg DNA.
2,3-epoxy-4-hydroxynonanal, a potential lipid peroxidation product for etheno adduct formation, is not a substrate of human epoxide hydrolase.
2,3-epoxy-4-hydroxynonanal is not a substrate of human epoxide hydrolase, and, thus, its possible endogenous role in the formation of promutagenic exocyclic etheno adducts in vivo is strengthened.
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Recognition of 1,N2-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active-site residue
It is proposed that other repair and tolerance mechanisms operate in the case of ϵG lesions, and that current models for etheno lesion repair in humans should be revised.