1,N2-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal cross-link to peptides via Schiff base linkage.

@article{Kurtz20031N2deoxyguanosineAO,
  title={1,N2-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal cross-link to peptides via Schiff base linkage.},
  author={Andrew J. Kurtz and R. Stephen Lloyd},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 8},
  pages={5970-6}
}
DNA-protein cross-links (DPCs) are formed upon exposure to a variety of chemical and physical agents and pose a threat to genomic integrity. In particular, acrolein and related aldehydes produce DPCs, although the chemical linkages for such cross-links have not been identified. Here, we report that oligodeoxynucleotides containing 1,N(2)-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal can form cross-links with the tetrapeptide Lys-Trp-Lys-Lys. We concluded that… CONTINUE READING
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Aldehyde-derived DNA Adducts Cross-link to Peptides 5976 by gest on N ovem er 14

  • I. G. Minko, Y. Zou, R. S. Lloyd
  • December 26,
  • 2002

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