1,4-cyclohexadiene-1-alanine (2,5-dihydrophenylalanine) a new inhibitor of phenylalanine for the rat and Leuconostoc dextranicum 8086.

@article{Snow196814cyclohexadiene1alanineA,
  title={1,4-cyclohexadiene-1-alanine (2,5-dihydrophenylalanine) a new inhibitor of phenylalanine for the rat and Leuconostoc dextranicum 8086.},
  author={Mary Lou Snow and Christine Lauinger and C. Ressler},
  journal={The Journal of organic chemistry},
  year={1968},
  volume={33 5},
  pages={
          1774-80
        }
}
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It is shown here that L-H(2)Phe is a secreted metabolite in Photorhabdus luminescens cultures and a precursor of a recently described 2,5-dihydrostilbene, illustrating the versatile metabolic rerouting of prephenate from aromatic amino acid synthesis to antibiotic synthesis. Expand
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Summaryl-2,5-Dihydrophenylalanine has been isolated from cultures of two strains of Streptomyces. The antibiotic activity of this compound is antagonized by Phenylalanine and… Expand
Synthesis of cyclohexa-1,4-dienephosphonoyl dichlorides
1,4-Cyclohexadiene and similar hydrocarbons can be prepared via the Birch reduction of aromatic hydrocarbons with metals in liquid ammonia [3]. However, this approach is limitedly applicable in the… Expand
Anti-persistent mycobacterial inhibitors from Streptomycessp. H7763 targeting isocitrate lyase andmalate synthase in the glyoxylate shunt of Mycobacterium sp.
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In the search for persistent TB Inhibitors from soil actinomycetes metabolites, a positive extract was obtained and the hits strain was identified and designated as Streptomyces sp. Expand
Stoffwechselprodukte von Mikroorganismen
  • H. Diekmann
  • Chemistry, Biology
  • Archiv für Mikrobiologie
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Coprogen B was transformed into chlorcoprogen by substitution and iodocoprogen resulted from the latter after halogen exchange, and a rule for the naming of metabolites with hydroxamic acid functions is suggested. Expand
Stoffwechselprodukte von Mikroorganismen
SummaryL-2,5-Dihydrophenylalanine inhibits the growth of E. coli K 12 in synthetic liquid media when added during the lag phase at a concentration of 5×10-5 M (8.35 γ/ml). The inhibition is reversed… Expand
The Birch Reduction of Aromatic Compounds
The reduction of aromatic compounds by alkali metals in liquid ammonia represents an important method for the preparation of partially unsaturated six-membered rings. The reaction was discovered by… Expand
Hydrolysis in Pharmaceutical Formulations
This literature review presents hydrolysis of active pharmaceutical ingredients as well as the effects on dosage form stability due to hydrolysis of excipients. Mechanisms and measurement methods are… Expand
1,4-Dihydro-l-phenylalanine-its synthesis and behavior in the phenylalanine ammonia-lyase reaction.
TLDR
Kinetic measurements with phenylalanine ammonia-lyase showed that 1,4-dihydro-l-phenylalanines is no substrate but a moderately good competitive inhibitor of the enzymatic reaction, providing further evidence for the plausibility of the recently proposed mechanism of action of phenylAlanine ammonia -lyase. Expand
L-2,5-dihydrophenylalanine, an inducer of cathepsin-dependent apoptosis in human promyelocytic leukemia cells (HL-60).
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Results indicated that DHPA was an inducer of cathepsin-dependent apoptosis in HL-60 cells, and this apoptosis was demonstrated by morphological changes and biochemical analysis. Expand
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