1,3-substituted imidazolidine-2,4,5-triones: synthesis and inhibition of cholinergic enzymes.

  title={1,3-substituted imidazolidine-2,4,5-triones: synthesis and inhibition of cholinergic enzymes.},
  author={Vladim{\'i}r Pejchal and {\vS}{\'a}rka {\vS}těp{\'a}nkov{\'a} and Zdeňka Padělkov{\'a} and Ale{\vs} Imramovsk{\'y} and Josef Jamp{\'i}lek},
  volume={16 9},
A series of novel and highly active acetylcholinesterase and butyrylcholinesterase inhibitors derived from substituted benzothiazoles containing an imidazolidine-2,4,5-trione moiety were synthesized and characterized. The molecular structure of 1-(2,6-diisopropyl-phenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-imidazolidine-2,4,5-trione (3g) was determined by single-crystal X-ray diffraction. Both optical isomers are present as two independent molecules in the triclinic crystal system… CONTINUE READING
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