• Corpus ID: 16823807

1,3-Glucan: Silver Bullet or Hot Air?

@article{Vetvicka201013GlucanSB,
  title={1,3-Glucan: Silver Bullet or Hot Air?},
  author={V{\'a}clav Vetvicka and Jana Větvi{\vc}kov{\'a}},
  journal={Open Glycoscience},
  year={2010},
  volume={3}
}
Glucansto a group of biologically active natural compounds called biological response modifiers. These substances represent highly conserved structural components of cell walls in yeast, fungi, grain and seaweed. The effects of � -glucan on immune reactions are well established however direct comparisons of the biological activities of several individual glucans are extremely rare. As this paper will show, we tested sixteen different glucans and evaluated the possibility whether individual… 

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References

SHOWING 1-10 OF 31 REFERENCES
Glucans as biological response modifiers.
TLDR
Physiological functions of glucan suggest the possible use of glucans not only as non-specific immunomodulator, but also as its possible future use as a drug.
β-Glucans, History, and the Present: Immunomodulatory Aspects and Mechanisms of Action
TLDR
The various mechanisms of effects and the ways glucans mediate their effects on defense reactions against infections are explained and possible alternatives such as synthetic oligosaccharides are considered.
PHYSIOLOGICAL EFFECTS OF DIFFERENT TYPES OF β-GLUCAN
TLDR
There is a yes-or-no effect suggesting that highly purified and highly active glucan will have pleiotropic impact, whereas poorly isolated and/or less active glucans will have only mediocre biological properties.
[Structure and biological activities of fungal beta-1,3-glucans].
  • T. Yadomae
  • Biology
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2000
TLDR
This paper summarizes the structure, biological activities, signaling, and metabolic degradation of fungal beta-1,3-glucans, which are beneficial and pharmacologically useful, while some strongly related to allergic and inflammatory adverse reactions.
An Evaluation of the Immunological Activities of Commercially Available β1, 3-Glucans
β1,3-glucan’s role as a biologically active immunomodulator has been well documented for over 40 years. Interest in the immunomodulatory properties of polysaccharides was initially raised after
A Comparison of Injected and Orally Administered β-glucans
TLDR
It is demonstrated that oral delivery of glucan resulted in significant immunological activity, which albeit slightly lower, corresponded with injectable application, and shows that these biological response modifiers can be similarly active when used in both injectable and oral form.
Orally administered marine (1-->3)-beta-D-glucan Phycarine stimulates both humoral and cellular immunity.
Studies in natural products chemistry
...
1
2
3
4
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