1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPARγ partial agonists.

Abstract

A new series of PPARγ partial agonists, 1,3-diphenyl-1H-pyrazole derivatives, were identified using an improved virtual screening scheme combining ligand-centric and receptor-centric methods. An in vitro assay confirmed the nanomolar binding affinity of 1,3-diphenyl-1H-pyrazole derivatives such as SP3415. We also characterized the competitive antagonism of… (More)
DOI: 10.1016/j.bmc.2010.09.068

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