1,3-Dinitrobenzene metabolism and protein binding.

  title={1,3-Dinitrobenzene metabolism and protein binding.},
  author={Ian T Reeve and Marion G. Miller},
  journal={Chemical research in toxicology},
  volume={15 3},
1,3-Dinitrobenzene is a testicular toxicant, which produces a lesion in the seminiferous tubules of the rat. In the present study, we investigated which subcellular fractions of the seminiferous tubules are capable of 1,3-dinitrobenzene metabolism and protein adduct formation. Subcellular fractions of the liver were used as positive controls and to further investigate potentially important binding proteins. Microsomes, cytosol, and mitochondria prepared from each tissue were incubated with 200… CONTINUE READING