1,3-Di-n-butylimidazolium tribromide [BBim]Br3: An efficient recyclable catalyst mediated synthesis of N-substituted azepines and their biological evaluation-interaction study with human serum albumin.

  title={1,3-Di-n-butylimidazolium tribromide [BBim]Br3: An efficient recyclable catalyst mediated synthesis of N-substituted azepines and their biological evaluation-interaction study with human serum albumin.},
  author={Swetha Kameswari Maddili and Rakhi Chowrasia and Vijaya Kumar Kannekanti and Hima Bindu Gandham},
  journal={Journal of photochemistry and photobiology. B, Biology},
5 Citations
Synthesis of pyrazolo[3,4-b]azepines and their antioxidant and antibacterial studies
New series of pyrazolo[3,4-b]azepines were synthesized by the reaction of 5-aminopyrazoles and pyruvic acid using l-proline as catalyst. It was developed by two methodologies: microwave-assisted
Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents.
Investigation of interaction studies with calf thymus DNA and synthesized benzothiazolyl triazolium derivatives revealed that human serum albumin could effectively transport compound 5q while molecular modelling studies showed that hydrophobic interactions as well as hydrogen bonds played a significant role in the interaction of compounds 5q with HSA.
Pharmaceutical significance of azepane based motifs for drug discovery: A critical review.
The structure-activity relationship (SAR) and molecular docking studies of potential bioactive compounds for future discovery of suitable drug candidates can serve as an inspiration for new ideas for design and development of less toxic and more powerful azepane-based drugs against numerous devastating diseases.


Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
Six previously undescribed N-(2,4-diaminopteridin-6-yl)methyldibenz[b,f]azepines with water-solubilizing O-carboxyalkyloxy or O-carboxybenzyloxy side chains at the 2'-position were synthesized and
Transition metal-catalyzed hetero-[5 + 2] cycloadditions of cyclopropyl imines and alkynes: dihydroazepines from simple, readily available starting materials.
This new hetero-[5 + 2] cycloaddition works well with aldimines, ketimine, and with substituted cyclopropanes and affords the desired dihydroazepines in excellent yields as single regioisomers.
Synthesis and Evaluation of 4-Fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as Selective Inhibitors of Phenylethanolamine N-Methyltransferase versus the α2-Adrenoceptor.
A small series of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines (4-fluoro-THBAs; 12−15) were synthesized and evaluated as inhibitors of phenylethanolamine N-methyltransferase (PNMT; EC
d-Fused [1]benzazepines with selective in vitro antitumor activity: synthesis and structure-activity relationships.
The synthesis of novel quinolino[3,2-d][1]benzazepines and pyrido[3+, 2,4-diarylpyrido]benZazepin-6-ones and -thiones is described, which have noteworthy activity and remarkable selectivity for renal cancer cell lines.
A facile, aqueous phase green synthetic protocol for the synthesis of 5,9b-dihydro-1H-[1,2,4]triazino[5,6-b]indole-3-ols/5,9b-dihydro-1H-[1,2,4]triazino[5,6-b]indole-3-thiols
Abstract 5,9b-Dihydro-1H-[1,2,4]triazino[5,6-b]indole-3-ols/5,9b-dihydro-1H-[1,2,4]triazino[5,6-b]indole-3-thiols were synthesized for the first time in water under neutral conditions by using
Caesium Iodide as an Efficient Catalyst for Synthesis of N-Substituted Azepines via Tandem Michael Addition and Cyclisation under Aqueous Conditions
A one-pot synthesis of N-substituted azepines under aqueous conditions is described. The synthesis of several azepines derivatives was carried out by reaction of 2,5-dimethoxytetrahydrofuran,
Efficient synthesis of 2,3,4,5-tetrahydro-1H-3-benzazepines by intramolecular Heck reaction
A new facile method for the synthesis of the pharmacologically interesting 3-benzazepine skeleton is described. The easily available iodinated benzene derivative 3 is alkylated with allyl halides
Synthesis, anti-inflammatory and ulcerogenicity studies of some substituted pyrimido[1,6-a]azepine derivatives.
New series of pyrimido[1,6-a]azepines were prepared through reaction of the key amino compound 4 with various reagents to give a variety of 3-N-substituted amino derivatives 5-13, which showed activity similar to or higher than diclofenac sodium with no or minimal gastric ulceration.
Synthesis and study the antimicrobial activity of novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives.
A series of novel 2-(1H-indol-3-yl)-N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives (5a-o) were synthesized by cyclization of corresponding 1-(2-(1H-indol-3-yl) ethyl)-3-phenylthiourea