1,3-Capryloyl-2-arachidonoyl glycerol activates α-secretase activity and suppresses Aβ40 secretion in A172 cells

@article{Tanabe200913Capryloyl2arachidonoylGA,
  title={1,3-Capryloyl-2-arachidonoyl glycerol activates α-secretase activity and suppresses Aβ40 secretion in A172 cells},
  author={Chiaki Tanabe and Maiko Ebina and Masashi Asai and Eugene Futai and Shoichi Ishiura},
  journal={Neuroscience Letters},
  year={2009},
  volume={450},
  pages={324-326}
}
Alzheimer's disease (AD) is characterized by the deposition of amyloid beta-peptide (Abeta), derived from amyloid precursor protein (APP). Membrane states, such as lipid components or membrane fluidity, are important for enzymes related to APP processing in meeting their substrates efficiently. We analyzed the effects of triglycerides combined with polyunsaturated fatty acids (PUFAs) and/or caprylic acids on APP proteolysis. Our results showed that 1,3-capryloyl-2-arachidonoyl glycerol (8A8… CONTINUE READING