1,3‐Benzodioxole‐Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin‐Bound Structure

  title={1,3‐Benzodioxole‐Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin‐Bound Structure},
  author={Cassandra Yong and Shane M. Devine and Anne‐Catherine Abel and Stefan Dominic Tomlins and Divya Muthiah and Xuexin Gao and Richard Callaghan and Michel O. Steinmetz and Andrea E. Prota and Ben Capuano and Peter J. Scammells},
Since the revelation of noscapine's weak anti‐mitotic activity, extensive research has been conducted over the past two decades, with the goal of discovering noscapine derivatives with improved potency. To date, noscapine has been explored at the 1, 7, 6′, and 9′‐positions, though the 1,3‐benzodioxole motif in the noscapine scaffold that remains unexplored. The present investigation describes the design, synthesis and pharmacological evaluation of noscapine analogues consisting of modifications… 


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