1,25-dihydroxyvitamin D3 receptors in rat lung during the perinatal period: regulation and immunohistochemical localization.

@article{Nguyen1990125dihydroxyvitaminDR,
  title={1,25-dihydroxyvitamin D3 receptors in rat lung during the perinatal period: regulation and immunohistochemical localization.},
  author={T M Nguyen and Huguette Guillozo and L. O. Marin and M. E. Dufour and Claude Tordet and John Wesley Pike and Mich{\`e}le Garab{\'e}dian},
  journal={Endocrinology},
  year={1990},
  volume={127 4},
  pages={1755-62}
}
We have previously reported that in contrast to what has been described in adult lung, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] has specific binding sites in rat fetal lung at the end of gestation, and it stimulates in vitro the phospholipid biosynthesis and surfactant release from fetal rat type II pneumocytes. In the present study an immunohistochemical technique using a rat monoclonal antibody (9A7 gamma) and binding studies were carried out on fresh lung tissues from fetal and newborn rats… CONTINUE READING

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