1,25-Dyhydroxyvitamin D₃ attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy.

@article{Jang2014125DyhydroxyvitaminDA,
  title={1,25-Dyhydroxyvitamin D₃ attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy.},
  author={Wooyoung Jang and Hee Ju Kim and Huan Li and Kwang Deog Jo and Moon Kyu Lee and Sun Hong Song and Hyun Ok Yang},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={451 1},
  pages={
          142-7
        }
}
BACKGROUND AND OBJECTIVES Dysregulation of the autophagy pathway has been suggested as an important mechanism in the pathogenesis of Parkinson's disease (PD). Therefore, modulation of autophagy may be a novel strategy for the treatment of PD. Recently, an active form of vitamin D₃ has been reported to have neuroprotective properties. Therefore, we investigated the protective, autophagy-modulating effects of 1,25-dyhydroxyvitamin D₃ (calcitriol) in an in vitro model of Parkinson's disease… CONTINUE READING
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