1,25-Dihydroxyvitamin-D3 treatment reduces cardiac hypertrophy and left ventricular diameter in spontaneously hypertensive heart failure-prone (cp/+) rats independent of changes in serum leptin.

@article{Mancuso2008125DihydroxyvitaminD3TR,
  title={1,25-Dihydroxyvitamin-D3 treatment reduces cardiac hypertrophy and left ventricular diameter in spontaneously hypertensive heart failure-prone (cp/+) rats independent of changes in serum leptin.},
  author={Peter Mancuso and Ayesha Rahman and Stephen D Hershey and Loredana Dandu and K. Nibbelink and Robert U. Simpson},
  journal={Journal of cardiovascular pharmacology},
  year={2008},
  volume={51 6},
  pages={559-64}
}
A number of investigators have observed insufficient 25-hydroxyvitamin D status in patients with congestive heart failure, suggesting a role for vitamin D insufficiency in the pathogenesis of this disorder. We have observed cardiac hypertrophy and collagen accumulation in rats deficient in vitamin D and in the hearts of vitamin D-receptor knockout mice. Our studies indicate that absence of vitamin D-mediated signal transduction and genomic activation results in cardiomyocytes overstimulation… CONTINUE READING

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