1,25-Dihydroxyvitamin D3 transcriptionally regulates tumour necrosis factor mRNA during HL-60 cell differentiation.

Abstract

We investigated TNF-alpha gene expression in HL-60 cells under the influence of 1,25(OH)2D3. Our results show that TNF-alpha gene expression is transcriptionally activated by 1,25(OH)2D3. Despite the increase of TNF-alpha mRNA, very little TNF protein is found in either supernatants or cell lysates of HL-60 cells cultured in the presence of the vitamin… (More)

Topics

Cite this paper

@article{Steffen1988125DihydroxyvitaminDT, title={1,25-Dihydroxyvitamin D3 transcriptionally regulates tumour necrosis factor mRNA during HL-60 cell differentiation.}, author={Morgan M Steffen and Yvon E. Cayre and Kirk R. Manogue and M. A. Moore}, journal={Immunology}, year={1988}, volume={63 1}, pages={43-6} }