1,25-Dihydroxyvitamin D3 increases type 1 interleukin-1 receptor expression in a murine T cell line.

@article{Lacey1993125DihydroxyvitaminDI,
  title={1,25-Dihydroxyvitamin D3 increases type 1 interleukin-1 receptor expression in a murine T cell line.},
  author={David L. Lacey and Jeanne M Erdmann and Hong Lin Tan},
  journal={Journal of cellular biochemistry},
  year={1993},
  volume={52 2},
  pages={159-70}
}
The biologically active metabolite of vitamin D3, 1,25 (OH)2 D3, exerts important immunoregulatory effects in addition to being a central mediator of calcium/phosphate metabolism. Utilizing an interleukin 1 responsive murine T cell line and 125I-interleukin 1 alpha, we show that 1,25 (OH)2 D3 (5,50 nM) enhanced 125I-interleukin 1 alpha binding up to almost… CONTINUE READING