1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells.

@article{Price1980125DihydroxyvitaminDI,
  title={1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells.},
  author={Paul A. Price and S A Baukol},
  journal={The Journal of biological chemistry},
  year={1980},
  volume={255 24},
  pages={11660-3}
}
Rat osteosarcoma cells respond to 1,25-dihydroxyvitamin D3 with a 6-fold increase in intracellular and secreted levels of the vitamin K-dependent protein of bone (BGP). The rise in intracellular BGP levels is half-maximal at 6.6 h and precedes the rise in medium BGP levels by 6 h, a time course which is consistent with the postulated steroid hormone action of 1,25-dihydroxyvitamin D3. This effect is achieved by physiological levels of 1,25-dihydroxyvitamin D3, with half of the maximal response… CONTINUE READING

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