1,25-Dihydroxyvitamin D3 enhances the growth of tumors in athymic mice inoculated with receptor rich osteosarcoma cells.

@article{Yamaoka1986125DihydroxyvitaminDE,
  title={1,25-Dihydroxyvitamin D3 enhances the growth of tumors in athymic mice inoculated with receptor rich osteosarcoma cells.},
  author={Kunio Yamaoka and Samuel L. Marion and Agust{\'i}n Gallegos and Mark R. Haussler},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={139 3},
  pages={
          1292-8
        }
}
We tested the influence of daily subcutaneous injections of 12.5 and 25 pmol of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the growth of tumors arising from intracutaneous inoculations of athymic nude mice with rat osteogenic sarcoma cells (ROS) and human melanoma cells. Both doses of 1,25(OH)2D3 increased plasma calcium levels after 3 weeks and produced a striking enhancement in tumor weight when the mice received 1,25(OH)2D3 receptor-rich ROS17/2.8 cells. In contrast, 1,25(OH)2D3 caused no… CONTINUE READING

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