1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis.

@article{Mayne2011125DihydroxyvitaminDA,
  title={1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis.},
  author={Christopher G. Mayne and Justin A Spanier and Lance M. Relland and Calvin B. Williams and Colleen Hayes},
  journal={European journal of immunology},
  year={2011},
  volume={41 3},
  pages={
          822-32
        }
}
Multiple sclerosis (MS) is an incurable autoimmune neurodegenerative disease. Environmental factors may be key to MS prevention and treatment. MS prevalence and severity decrease with increasing sunlight exposure and vitamin D(3) supplies, supporting our hypothesis that the sunlight-dependent hormone, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2) D(3) ), inhibits autoimmune T-cell responses in MS. Moreover, 1,25-(OH)(2) D(3) inhibits and reverses experimental autoimmune encephalomyelitis (EAE), an… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
50 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Vitamin D and multiple sclerosis

  • C. E. Hayes, F. E. Nashold, C. G. Mayne, J. A. Spanier, C. D. Nelson
  • Vitamin D,
  • 2010

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

  • ANZgene Consortium
  • Nat. Genet
  • 2009

receptor gene polymorphisms for vitamin D research in multiple sclerosis

  • O. Torkildsen, P. M. Knappskog, H. I. Nyland, K. M. Myhr
  • Autoimmun. Rev
  • 2009

A Phase I/II dose-escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis

  • J. M. Burton, S. Kimball, +4 authors S Kilborn
  • Mult. Scler
  • 2008

Similar Papers

Loading similar papers…