1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age.

@article{Haussler2016125DihydroxyvitaminDA,
  title={1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age.},
  author={Mark R. Haussler and Grahame Whitfield and Carol A. Haussler and Marya S. Sabir and Zainab A Khan and Ruby Sandoval and Peter W Jurutka},
  journal={Vitamins and hormones},
  year={2016},
  volume={100},
  pages={165-230}
}
1,25-Dihydroxyvitamin D3 (1,25D) is the renal metabolite of vitamin D that signals through binding to the nuclear vitamin D receptor (VDR). The ligand-receptor complex transcriptionally regulates genes encoding factors stimulating calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling exerts feedback control of Ca/PO4 via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic… CONTINUE READING
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