1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine
@article{Norman1971125DihydroxycholecalciferolIO, title={1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine}, author={A. Norman and James F. Myrtle and Ronald J. Miogett and H. Nowicki and V. Williams and G. Popja�k}, journal={Science}, year={1971}, volume={173}, pages={51 - 54} }
The major polar metabolite of cholecalciferol (vitamin D3) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C27H4403 and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously… CONTINUE READING
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