1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine

@article{Norman1971125DihydroxycholecalciferolIO,
  title={1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine},
  author={A. Norman and James F. Myrtle and Ronald J. Miogett and H. Nowicki and V. Williams and G. Popja�k},
  journal={Science},
  year={1971},
  volume={173},
  pages={51 - 54}
}
  • A. Norman, James F. Myrtle, +3 authors G. Popja�k
  • Published 1971
  • Chemistry, Medicine
  • Science
  • The major polar metabolite of cholecalciferol (vitamin D3) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C27H4403 and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously… CONTINUE READING
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