1,25‐Dihydroxyvitamin D3 Regulates the Synthesis of γ‐Glutamyl Transpeptidase and Glutathione Levels in Rat Primary Astrocytes

@article{Garion1999125DihydroxyvitaminDR,
  title={1,25‐Dihydroxyvitamin D3 Regulates the Synthesis of $\gamma$‐Glutamyl Transpeptidase and Glutathione Levels in Rat Primary Astrocytes},
  author={Emmanuel Garçion and Laurence Sindji and G{\'e}rard Leblondel and Philippe Brachet and Françoise Darcy},
  journal={Journal of Neurochemistry},
  year={1999},
  volume={73}
}
Abstract : Astrocytes play a pivotal role in CNS detoxification pathways, where glutathione (GSH) is involved in the elimination of oxygen and nitrogen reactive species such as nitric oxide. We have previously demonstrated that the specific activity of γ‐glutamyl transpeptidase (γ‐GT), an enzyme of central significance in GSH metabolism, is regulated in vivo in astrocytes by 1,25‐dihydroxyvitamin D3 (1,25‐D3). The aim of the present work was to investigate, in primary cultures of newborn rat… 

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1,25-dihydroxyvitamin D3 regulates γ-glutamyl transpeptidase activity in rat brain

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Investigation into the role of gamma-GT in the extracellular metabolism of GSH indicates that resistant tumor cells metabolize two-fold more GSH than do sensitive cells and that such metabolism results in a similar difference in the intracellular concentration of cysteine.
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