1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.

@article{Borst2014125OH2VD,
  title={1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.},
  author={Oliver Borst and Patrick Muenzer and Evi Schmid and Eva-Maria Schmidt and Antonella Russo and Britta L Walker and Wenting Yang and Christina B. Leibrock and Kalina Szteyn and Sebastian Schmidt and Margitta Elvers and Caterina Faggio and Ekaterina Shumilina and Makoto Kuro-O and Meinrad P. Gawaz and Florian Lang},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014},
  volume={28 5},
  pages={
          2108-19
        }
}
Platelets are activated by increased cytosolic Ca(2+) concentration ([Ca(2+)]i) following store-operated calcium entry (SOCE) accomplished by calcium-release-activated calcium (CRAC) channel moiety Orai1 and its regulator STIM1. In other cells, Ca(2+) transport is regulated by 1,25(OH)2 vitamin D3 [1,25(OH)2D3]. 1,25(OH)2D3 formation is inhibited by klotho and excessive in klotho-deficient mice (kl/kl). The present study explored the effect of klotho deficiency on platelet Ca(2+) signaling and… CONTINUE READING
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