1,25(OH)2-vitamin D3, a steroid hormone that produces biologic effects via both genomic and nongenomic pathways.

@article{Norman1992125OH2vitaminDA,
  title={1,25(OH)2-vitamin D3, a steroid hormone that produces biologic effects via both genomic and nongenomic pathways.},
  author={Anthony W. Norman and Ilka Nemere and Lai X Zhou and June E. Bishop and Kathleen Lowe and Anita C. Maiyar and Elaine D Collins and T Taoka and Igor N. Sergeev and Mary C. Farach-Carson},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1992},
  volume={41 3-8},
  pages={231-40}
}
The hormonally active form of vitamin D is 1,25(OH)2-vitamin D3 [1,25(OH)2D3]. This seco-steroid is the key mediator of the vitamin D endocrine system which produces biological effects in over 28 target tissues. In these target tissues, the biological responses may be generated both by a signal transduction mechanism which involves a nuclear receptor for 1,25(OH)2D3 that modulates gene transcription or a signal transduction pathway which involves rapid opening of Ca2+ channels which are… CONTINUE READING