1,25(OH)(2)D(3) stimulates Mg2+ uptake into MDCT cells: modulation by extracellular Ca2+ and Mg2+.

@article{Ritchie2001125OH2D3SM,
  title={1,25(OH)(2)D(3) stimulates Mg2+ uptake into MDCT cells: modulation by extracellular Ca2+ and Mg2+.},
  author={Gordon Ritchie and Dirk Kerstan and L J Dai and Hoon Kang and Lucie Canaff and Geoffrey N Hendy and Gary A. Quamme},
  journal={American journal of physiology. Renal physiology},
  year={2001},
  volume={280 5},
  pages={
          F868-78
        }
}
The distal convoluted tubule plays a significant role in renal magnesium conservation. Although the cells of the distal convoluted tubule possess the vitamin D receptor, little is known about the effects of 1alpha,25-dihydroxyvitamin D [1,25(OH)(2)D(3)] on magnesium transport. In this study, we examined the effect of 1,25(OH)(2)D(3) on distal cellular magnesium uptake and the modulation of this response by extracellular Ca2+ and Mg2+ in an immortalized mouse distal convoluted tubule (MDCT) cell… CONTINUE READING