1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice.

@article{Wang201712DichloroethaneIG,
  title={1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice.},
  author={Ting Wang and Dandan Xu and Qi-ming Fan and Weifeng Rong and Jiewei Zheng and Chen Gao and Guoliang Li and Ni Zeng and Tao Guo and Lihai Zeng and Fei Wang and Chen Xiao and Li Cai and Shangqing Tang and Xinlei Deng and Xiao Lin Yin and Manqi Huang and Fengrong Lu and Qiansheng Hu and Wen Chen and Zhenlie Huang and Qing Wang},
  journal={Toxicology},
  year={2017},
  volume={380},
  pages={
          38-49
        }
}
Excessive exposure to 1,2-Dichloroethane (1,2-DCE), a chlorinated organic toxicant, can lead to liver dysfunction. To fully explore the mechanism of 1,2-DCE-induced hepatic abnormalities, 30 male National Institutes of Health (NIH) Swiss mice were exposed to 0, 350, or 700mg/m3 of 1,2-DCE, via inhalation, 6h/day for 28days. Increased liver/body weight ratios, as well as serum AST and serum ALT activity were observed in the 350 and 700mg/m3 1,2-DCE exposure group mice, compared with the control… CONTINUE READING