1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.

  title={1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.},
  author={Sean R. Klopfenstein and Artem G. Evdokimov and A O Colson and Neil T. Fairweather and Jeffrey J. Neuman and Matthew B. Maier and Jeffrey L. Gray and Gina S. Gerwe and George E. Stake and Brian W. Howard and Julie A. Farmer and Matthew E. Pokross and Thomas Downs and B. Kasibhatla and Kevin G. Peters},
  journal={Bioorganic & medicinal chemistry letters},
  volume={16 6},
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.