1,1-Dichloroethylene: an apoptotic hepatotoxin?

  title={1,1-Dichloroethylene: an apoptotic hepatotoxin?},
  author={Edward S. Reynolds and Mary F. Kanz and Pasquale Chieco and Mary Treinen Moslen},
  journal={Environmental Health Perspectives},
  pages={313 - 320}
Within 2 hr after 1,1-dichloroethylene administration, the following phenomena occur in livers of fasted rats: dilation and disruption of bile canaliculi, plasma membrane invagination and loss of microvilli, cytoplasmic vacuolation, and loss of density in mitochondrial matrices. Early, selective loss of enzyme activities was localized by histochemical staining to bile canalicular, and inner and outer mitochondrial membranes. Biliary permeability to inulin increased, a change suggestive of the… CONTINUE READING


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Rapid , functional canalicular injury and cholestasis in rats given 1 , 1 - dichloroethylene ( abstr . )

  • E. Elias, Z. Hruban, J. B. Wade, J. L. Boyer
  • Federation Proc .
  • 1983

Early loss of hepatic glutathione transferase activities in 1 , 1 - dichloroethylene poisoned rats ( abstr . )

  • B. Botti, M. T. Moslen, N. M. Trieff, E. S. Reynolds
  • Toxicologist
  • 1981

W The nature of piecemeal necrosis in chronic active hepatitis

  • M. T. Moslen, L. R. Poisson, E. S. Reynolds
  • 1979

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