1,1,3,3-tetrachloroacetone: teratogenicity study in mice and rabbits.

  title={1,1,3,3-tetrachloroacetone: teratogenicity study in mice and rabbits.},
  author={Joseph John and Francis J. Murray and John F. Quast and P A Keeler and Bernard A Schwetz and Robert E. Staples},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={2 5},
The teratogenicity of tetrachloroacetone (TCA) was evaluated in CF-1 mice and New Zealand white rabbits. Mice were given 0, 5, 15 or 50 mg/kg/day of TCA by gavage on days 6 through 15 of gestation. Rabbits were given 0, 1, 5, or 10 mg/kg/day on days 6 through 18 of gestation. The incidence of malformed fetuses was not significantly increased among mice given 5, 15 or 50 mg/kg/day of TCA. Sixteen fetuses in 3 litters in the 50 mg/kg/day group had cleft palate; they were from three dams which… CONTINUE READING
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