1,1,1,3,3,3-Hexafluoroisopropanol as a Remarkable Medium for Atroposelective Sulfoxide-Directed Fujiwara-Moritani Reaction with Acrylates and Styrenes.

@article{Dherbassy2016111333HexafluoroisopropanolAA,
  title={1,1,1,3,3,3-Hexafluoroisopropanol as a Remarkable Medium for Atroposelective Sulfoxide-Directed Fujiwara-Moritani Reaction with Acrylates and Styrenes.},
  author={Quentin Dherbassy and Geoffrey Schwertz and Matthieu Chess{\'e} and Chinmoy Kumar Hazra and Joanna Wencel-Delord and Françoise Colobert},
  journal={Chemistry},
  year={2016},
  volume={22 5},
  pages={
          1735-43
        }
}
Axially chiral biaryls are ubiquitous structural motifs of biologically active molecules and privileged ligands for asymmetric catalysis. Their properties are due to their configurationally stable axis, and therefore, the control of their absolute configuration is essential. Efficient access to atropo-enantioenriched biaryl moieties through asymmetric direct C-H activation, by using enantiopure sulfoxide as both the directing group (DG) and chiral auxiliary, is reported. The stereoselective… CONTINUE READING
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