06-P045 A G11A mutation N-terminal to the polyalanine tract in HOXD13 causes limb malformations by altering both the stability and the DNA-binding functions of HOXD13


Dynamic expressions of Homeobox (Hox) genes along the anterior-posterior axis of the neural tube (NT) are crucial in body patterning and neural crest (NC) development. At E12.5, Hoxb5 expression extends from the hindbrain throughout the entire NT with dorsally-restricted expression. By replacing the transactivation domain of Hoxb5 with a transcription… (More)
DOI: 10.1016/j.mod.2009.06.271