02-P001 Caspase3 and the homeodomain-containing gene Barhl2 act as brakes on neuroepithelial cell proliferation by inhibiting β-catenin activation

@article{Durand200902P001CA,
  title={02-P001 Caspase3 and the homeodomain-containing gene Barhl2 act as brakes on neuroepithelial cell proliferation by inhibiting β-catenin activation},
  author={B{\'e}atrice Durand and J{\'e}r{\^o}me Ausseil and Dimeng Shi and Marion Wassef},
  journal={Mechanisms of Development},
  year={2009},
  volume={126}
}
Little is known about the respective contributions of cell proliferation and cell death to the control of vertebrate forebrain growth. The homeodomain containing gene barhl2 is expressed in the diencephalon of Xenopus, zebrafish, and mouse embryos, and we previously showed that its over-expression in Xenopus neuroepithelial cells induces Caspase3-dependent apoptosis. These findings suggested that Barhl2 and Caspase3 might be involved in diencephalic growth and morphogenesis. Consistent with… CONTINUE READING
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