(r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia

@article{Frlich2004rBN,
  title={(r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia},
  author={Lutz Fr{\"o}lich and Mario E. G{\"o}tz and Michael Weinm{\"u}ller and Moussa B. H. Youdim and N. Barth and A. S. Dirr and Wieland Gsell and Kurt A. Jellinger and Helmut Beckmann and Peter Franz Riederer},
  journal={Journal of Neural Transmission},
  year={2004},
  volume={111},
  pages={295-310}
}
Summary.In dementia of Alzheimer type (DAT), cerebral glucose metabolism is reduced in vivo, and enzymes involved in glucose breakdown are impaired in post-mortem brain tissue. Pyruvate dehydrogenase complex activity (PDHc) is one of the enzymes known to be reduced, while succinate dehydrogenase activity (SDH), another enzyme of oxidative glucose metabolism is unchanged. In dementia of vascular type (DVT), variable changes in glucose metabolism have been demonstrated in vivo, while changes of… Expand
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