(Tpeak - Tend)/QRS and (Tpeak - Tend)/(QT × QRS): novel markers for predicting arrhythmic risk in the Brugada syndrome.

@article{Tse2017TpeakT,
  title={(Tpeak - Tend)/QRS and (Tpeak - Tend)/(QT × QRS): novel markers for predicting arrhythmic risk in the Brugada syndrome.},
  author={Gary Tse},
  journal={Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology},
  year={2017},
  volume={19 4},
  pages={
          696
        }
}
  • G. Tse
  • Published 2017
  • Medicine
  • Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
I read the recent paper by Zumhagen et al . with great interest, who demonstrated that the interval from the peak to the end of the electrocardiographic T wave (Tpeak − Tend) and (Tpeak − Tend)/QT ratio, were strong risk markers for Brugada patients with life-threatening ventricular arrhythmias.1 These ratios reflect the transmural dispersion of repolarization (TDR), increases in which can lead to unidirectional conduction block and reentry. … 
Novel arrhythmic risk markers incorporating QRS dispersion: QRSd × (Tpeak − Tend)/QRS and QRSd × (Tpeak − Tend)/(QT × QRS)
  • G. Tse, B. Yan
  • Medicine
  • Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
  • 2017
TLDR
Two novel indices are proposed that may have a higher accuracy in risk stratification and have the potential of having superior predictive values than ventricular repolarization markers such as QTc, QTd, T peak − Tend, or (Tpeak − Tend)/QT ratio. Expand
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TLDR
This meta-analysis showed that Tpeak-Tend interval is significant higher in individuals who are at elevated risk of adverse events in congenital LQTS, offering incremental value for risk stratification. Expand
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The molecular determinants of the AP duration and the causes of long and short QT syndromes (LQTS and SQTS) are explored and a discussion on strategies for the future rational design of anti-arrhythmic agents is discussed. Expand
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TLDR
Specific ECG markers based on depolarization and/or repolarization that have been associated with an increased risk of arrhythmic events in patients with BrS are highlighted. Expand
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TLDR
The Brugada syndrome is an inherited disorder associated with risk of ventricular fibrillation and sudden cardiac death in a structurally normal heart and in approximately 30% of patients, a genetic variant may be implicated in causation after a comprehensive analysis. Expand
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This letter attempts to provide a brief overview to illustrate the importance of understanding the limitations of experimental methods and the need to appraise experimental data. Expand
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TLDR
Hypercalcemia treatment exerted anti-arrhythmic effects during hyperkalemia, reducing the proportion of hearts showing VT to 1 of 7 hearts, and epicardial VERPs without further altering the remaining parameters, returning VERP/latency ratio to normokalemic values and also decreased the critical intervals. Expand
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TLDR
Evidence from computational modelling, pre-clinical and clinical studies illustrates that molecular abnormalities found in BrS lead to alterations in excitation wavelength (λ), which ultimately elevates arrhythmic risk. Expand
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References

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Tpeak-Tend interval and Tpeak-Tend/QT ratio in patients with Brugada syndrome.
TLDR
Assessment of the Tpeak-Tend intervals or the TpTe/QT ratio in lead V1 is potentially useful as a non-invasive risk marker for BrS patients with life-threatening arrhythmias. Expand
A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
TLDR
The data from 7 reference drugs of known pro-arrhythmic effects suggests that this non-invasive iCEB predicts potential risk of drug-induced CAs beyond long QT and TdP, and is more useful than the current biomarkers (i.e. transmural dispersion and instability) in predicting potential risks for drug- induced non-TdP-like VT/VF. Expand
Prolonged QRS duration in lead V2 and risk of life-threatening ventricular Arrhythmia in patients with Brugada syndrome.
TLDR
Prolonged QRS duration as measured on a standard 12-lead ECG is associated with ventricular arrhythmia and could serve as a simple noninvasive marker of vulnerability to life-threatening cardiac events in patients with Brugada syndrome. Expand
Cardiac dynamics: Alternans and arrhythmogenesis
TLDR
The mechanisms that generate cardiac repolarization alternans are reviewed and a discussion on how alternans generate arrhythmias in a number of clinical scenarios is discussed, followed by an outline of future therapeutic targets for anti‐arrhythmic therapy. Expand