(RS)-Propranolol: enantioseparation by HPLC using newly synthesized (S)-levofloxacin-based reagent, absolute configuration of diastereomers and recovery of native enantiomers by detagging.

@article{Alwera2016RSPropranololEB,
  title={(RS)-Propranolol: enantioseparation by HPLC using newly synthesized (S)-levofloxacin-based reagent, absolute configuration of diastereomers and recovery of native enantiomers by detagging.},
  author={Shiv Alwera and R. Bhushan},
  journal={Biomedical chromatography : BMC},
  year={2016},
  volume={30 8},
  pages={
          1223-33
        }
}
  • Shiv Alwera, R. Bhushan
  • Published 2016
  • Chemistry, Medicine
  • Biomedical chromatography : BMC
    • Diastereomers of (RS)-propranolol were synthesized using (S)-levofloxacin-based new chiral derivatizing reagents (CDRs). Levofloxacin was chosen as the pure (S)-enantiomer for its high molar absorptivity (εo  ∼ 24000) and availability at a low price. Its -COOH group had N-hydroxysuccinimide and N-hydroxybenzotriazole, which acted as good leaving groups during nucleophilic substitution by the amino group of the racemic (RS)-propranolol; the CDRs were characterized by UV, IR, (1) H-NMR, high… CONTINUE READING
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