(Phenylpiperazinyl)cyclohexylureas: discovery of alpha1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS).

Abstract

Benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) can be effectively treated with alpha(1) adrenergic receptor antagonists. Unfortunately, currently marketed alpha(1) blockers produce CV-related side effects that are caused by the subtype non-selective nature of the drugs. To overcome this problem, it was postulated that an alpha(1a/1d… (More)

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Cite this paper

@article{Chiu2008PhenylpiperazinylcyclohexylureasDO, title={(Phenylpiperazinyl)cyclohexylureas: discovery of alpha1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS).}, author={George Chiu and Shengjian Li and Peter J. Connolly and Virginia L Pulito and Jingchun Liu and Steven A. Middleton}, journal={Bioorganic & medicinal chemistry letters}, year={2008}, volume={18 2}, pages={640-4} }