(Mela)statin' the not so obvious: tumor suppressor hidden in intron.

  title={(Mela)statin' the not so obvious: tumor suppressor hidden in intron.},
  author={Ashley M Poenitzsch and Vijayasaradhi Setaluri and Vladimir S. Spiegelman},
  journal={Pigment cell & melanoma research},
  volume={24 2},
The complex molecular mechanisms involved in the development and progression of cutaneous malignant melanoma remain incompletely understood. Small 22-nucleotide microRNAs (miRNAs), which are becoming increasingly known to be associated with tumorigenesis, may now offer insight into the aggressively invasive behavior of melanoma. This new class of small RNAs targets mRNA turnover and translation thereby affecting proteins participating in cellular processes such as proliferation, apoptosis and… CONTINUE READING