(Healthy) Ageing: Focus on Iodothyronines

@inproceedings{Lange2013HealthyAF,
  title={(Healthy) Ageing: Focus on Iodothyronines},
  author={Pieter de Lange and Federica Cioffi and Elena Silvestri and Maria Moreno and Fernando Goglia and Antonia Lanni},
  booktitle={International journal of molecular sciences},
  year={2013}
}
The activity of the thyroid gland diminishes during ageing, but a certain tissue reserve of T3 and its metabolites is maintained. This reserve is thought to play a regulatory role in energy homeostasis during ageing. This review critically assesses this notion. T3 was thought to act predominantly through pathways that require transcriptional regulation by thyroid hormone receptors (TRs). However, in recent years, it has emerged that T3 and its metabolites can also act through non-genomic… CONTINUE READING

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