(99m)technetium-HYNIC(tricine/TPPTS)-Aca-bombesin(7-14) as a targeted imaging agent with microSPECT in a PC-3 prostate cancer xenograft model.

@article{Ananias201199mtechnetiumHYNICtricineTPPTSAcab,
  title={(99m)technetium-HYNIC(tricine/TPPTS)-Aca-bombesin(7-14) as a targeted imaging agent with microSPECT in a PC-3 prostate cancer xenograft model.},
  author={Hildo J. K. Ananias and Zilin Yu and Rudi A. J. O. Dierckx and Christophe van der Wiele and Wijnand Helfrich and Fan Wang and Yongjun Yan and Xiaoyuan Chen and Igle Jan de Jong and Philip H. Elsinga},
  journal={Molecular pharmaceutics},
  year={2011},
  volume={8 4},
  pages={1165-73}
}
The peptide bombesin (BN) and derivates thereof show high binding affinity for the gastrin-releasing peptide receptor (GRPR), which is highly expressed in primary and metastasized prostate cancer. We have synthesized a new BN-based radiopharmaceutical (99m)technetium-HYNIC(tricine/TPPTS)-Aca-BN(7-14) ((99m)Tc-HABN) and evaluated its GRPR targeting properties in vitro and in a xenograft tumor model for human prostate cancer in athymic mice. (99m)Tc-HABN was synthesized, and its lipophilicity and… CONTINUE READING

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The peptide bombesin ( BN ) and derivates thereof show high binding affinity for the gastrin - releasing peptide receptor ( GRPR ) , which is highly expressed in primary and metastasized prostate cancer .
GRPR geneGene encodes gene productBombesin Receptor
The peptide bombesin ( BN ) and derivates thereof show high binding affinity for the gastrin - releasing peptide receptor ( GRPR ) , which is highly expressed in primary and metastasized prostate cancer .
The peptide bombesin ( BN ) and derivates thereof show high binding affinity for the gastrin - releasing peptide receptor ( GRPR ) , which is highly expressed in primary and metastasized prostate cancer .
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