(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent.

  title={(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent.},
  author={K. Desino and S. Ansar and G. Georg and R. Himes and M. Michaelis and D. Powell and E. A. Reiff and H. Telikepalli and K. Audus},
  journal={Journal of medicinal chemistry},
  volume={52 23},
  • K. Desino, S. Ansar, +6 authors K. Audus
  • Published 2009
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • Compounds that interact with microtubules, such as paclitaxel, have been shown to possess protective properties against beta-amyloid (Abeta) induced neurodegeneration associated with Alzheimer's disease. In this work, the novel agent (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol was investigated for effectiveness in protecting neurons against several toxic stimuli and its interaction with the microtubule network. Exposure of neuronal cultures to Abeta… CONTINUE READING
    5 Citations


    β-Amyloid-Induced Neurodegeneration and Protection by Structurally Diverse Microtubule-Stabilizing Agents
    • 93
    • PDF
    A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach.
    • 29
    Amyloid peptide toxicity and microtubule-stabilizing drugs
    • 20
    A fluorescence-based high-throughput assay for antimicrotubule drugs.
    • 63
    The effects of dimethyl sulfoxide on the kinetics of tubulin assembly.
    • 43
    Protection against beta-amyloid toxicity in primary neurons by paclitaxel (Taxol).
    • 31