(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent.

@article{Desino20093R5S7as35Bis4fluorophenyltetrahydro,
  title={(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent.},
  author={K. Desino and S. Ansar and G. Georg and R. Himes and M. Michaelis and D. Powell and E. A. Reiff and H. Telikepalli and K. Audus},
  journal={Journal of medicinal chemistry},
  year={2009},
  volume={52 23},
  pages={
          7537-43
        }
}
  • K. Desino, S. Ansar, +6 authors K. Audus
  • Published 2009
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • Compounds that interact with microtubules, such as paclitaxel, have been shown to possess protective properties against beta-amyloid (Abeta) induced neurodegeneration associated with Alzheimer's disease. In this work, the novel agent (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol was investigated for effectiveness in protecting neurons against several toxic stimuli and its interaction with the microtubule network. Exposure of neuronal cultures to Abeta… CONTINUE READING
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