(15)O-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases.

@article{Lubberink201515OWaterPS,
  title={(15)O-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases.},
  author={Mark Lubberink and Sanjeep S.V. Golla and My Jonasson and Kristofer Rubin and Bengt Glimelius and Jens S{\"o}rensen and Peter Nygren},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2015},
  volume={56 8},
  pages={
          1144-9
        }
}
UNLABELLED High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of antitumor drugs. Imatinib, a selective inhibitor of platelet-derived growth factor receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown but should be reflected by an increase in water… CONTINUE READING
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